4th International Meeting on Quadruplex Nucleic Acids

The 4th International Meeting on G-quadruplex Nucleic Acids will commence at 1:30pm on 1-July-2013 and end at 3.45pm on 4-July-2013.

Guided tour of Singapore is scheduled for the afternoon of July 3, 2013 and is free for all conference participants and their accompanying guests.

Download: Program

Monday, 1 July 2013 Tuesday, 2 July 2013 Wednesday, 3 July 2013 Thursday, 4 July 2013

Day 1: Monday, 1 July 2013
11.30 – 13.30Registration
13.30 – 13.45 Welcome
 Session Chair: Alain Nicolas
13.45 – 14.30 Keynote Lecture 1
Nancy Maizels, University of Washington, USA
The G4 genome
14.30 – 15.00 Zheng Tan, Chinese Academy of Sciences, China
Co-transcriptional formation of DNA:RNA hybrid G-quadruplex: Evolutional selection, mechanism of formation, and regulation on transcription
15.00 – 15.30 Shantanu Chowdhury, Institute of Genomics and Integrative Biology, India
Guanine-quadruplex-mediated gene regulation controls metastases in lung cancer cells
15.30 – 15.45 Sara N. Richter, University of Padua, Italy
A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter
15.45 – 16.00 Vladimir Kuznetsov, Bioinformatics Institute, Singapore
The genome wide cartography of the evolutionarily conserved R-loop formation sequences (RLFS) reveals thousands prevalence sites of G-quadruplexes (G4s), and G4-Rloop structures involving in transcriptional regulation
16.00 – 16.30 Coffee Break
 Session Chair: Vitaly V Kuryavyi
16.30 – 17.00 Janez Plavec, National Institute of Chemistry, Slovenia
NMR structures of G-quadruplexes with unique features
17.00 – 17.30 Hiroshi Sugiyama, Kyoto University, Japan
Direct observation of the G-hairpin and G-triplex intermediates
17.30 – 18.00 Antonio Randazzo, University of Naples Federico II, Italy
Targeting G-quadruplexes, knowing G-triplex
18.00 – 18.15 Kah Wai Lim, Nanyang Technological University, Singapore
Structural basis of DNA quadruplex-duplex junction formation
18.15 – 18.30 Gary Parkinson, University College London, UK
Structural investigation into human telomeric quadruplex/duplex interfaces
19.00 – 21.00 Dinner and Poster Session 1


Day 2: Tuesday, 2 July 2013
 Session Chair: Laurent Lacroix
8.45 – 9.15 Jean-Louis Mergny, Institut Européende Chimie et Biologie, France
Quadruplexes are everywhere!
9.15 – 9.45 Hanbin Mao, Kent State University, USA
Population dynamics in human telomeric RNA sequence is modulated by G-quadruplex binding ligands
9.45 – 10.00 Iztok Prislan, University of Ljubljana, Slovenia
Kinetics of G-quadruplexes in all its terrible beauty
10.00 – 10.15 Danny Porath, Hebrew University of Jerusalem, Israel
Charge transport in single DNA-based molecules
10.15 – 10.30 Mahesh Uttamchandani, National University of Singapore
Visual DNA detection using asymmetric PCR and G-quadruplexes: An integrated workflow
10.30 – 12.30 Coffee Break and Poster Session 2
12.30 – 14.00 Lunch and Poster Session 3
 Session Chair: Marie-Paule Teulade-Fichou
14.00 – 14.30 Kazuo Nagasawa, Tokyo University of Agriculture & Technology, Japan
G-quadruplex ligands with macrocyclicpolyoxazoles
14.30 – 15.00 Dik-Lung Ma, Hong Kong Baptist University
Luminescent G-quadruplex-based probes
15.00 – 15.30 Xiaogang Qu, Chinese Academy of Sciences, China
New insights into ligand-telomeric DNA interactions and their applications
15.30 – 15.45 Huaqiang Zeng, National University of Singapore
Cationic macrocyclic aromatic pentamers as a new class of highly specific telomere RNA G-quadruplex-binding ligands
15.45 – 16.00 Mauro Freccero, UniversitÓ di Pavia, Italy
Covalent targeting of G-quadruplex structures by naphthalene diimide conjugated electrophiles
16.00 – 16.30 Coffee Break
 Session Chair: Nancy Maizels
16.30 – 17.00 Alain Nicolas, Institut Curie, France
Biological role of G-quadruplexes in replication and genome instability
17.00 – 17.30 Tracy Bryan, University of Sydney, Australia
Functions of telomeric G-quadruplexes in ciliates and humans
17.30 – 17.45 Herman O. Sintim, University of Maryland, USA
The biological implications of G-quadruplex formation by cyclic dinucleotide, c-di-GMP, at low micromolar concentrations
17.45 – 18.00 Jean-Pierre Perreault, Universite de Sherbrooke, Canada
Sequence specific modulation of G-quadruplex folding
18.00 – 18.15 Wouter Koole, Leiden University Medical Center, The Netherlands
An alternative end-joining pathway prevents genomic instability at G4 DNA sites
18.30 – 20.00Light Dinner and Poster Session 4


Day 3: Wednesday, 3 July 2013
 Session Chair: Daniela Rhodes
8.45 – 9.30 Keynote Lecture 2
Shankar Balasubramanian, University of Cambridge, UK
Studying G-quadruplex formation in the genome
9.30 – 10.00 Jörg Hartig, University of Konstanz, Germany
Properties and potential functions of bacterial quadruplex sequences
10.00 – 10.15 Linda B. McGown, Rensselaer Polytechnic Institute, USA
Capture and identification of genomic G4 DNA binding proteins
10.00 – 10.30 Luigi E. Xodo, University of Udine, Italy
Design of new strategies involving nucleic acid quadruplexes to inhibit the KRAS oncogene in cancer cells
10.30 – 11.00 Coffee Break
 Session Chair: Antonio Randazzo
11.00 – 11.30 Dipankar Sen, Simon Fraser University, Canada
Catalytic and switching properties of DNA G-quadruplexes
11.30 – 12.00 Valérie Gabelica, Institut Européende Chimieet Biologie, France
Interplay between cation and ligand binding to G-quadruplexes: Insight from mass spectrometry
12.00 – 12.15 Peter Mojzeš, Charles University, Czech Republic
Raman spectroscopic studies of G-quadruplexes at high DNA concentration
12.15 – 12.30 Daniela Verga, University of Konstanz, Germany
Photocrosslinking Quadruplex DNA
12.30 – 14.00 Lunch and Poster Session 5
14.00 – 18.30 Free Afternoon – Guided Tour
19.00 – 22.00 Banquet


Day 4: Thursday, 4 July 2013
 Session Chair: Gary Parkinson
8.45 – 9.30 Keynote Lecture 3
Laurence H. Hurley, University of Arizona, USA
The BCL-2 promoter DNA i-motif exists in a dynamic state that allows for transcriptional regulation and drug targeting to produce chemosensitization
9.30 – 10.00 Danzhou Yang, University of Arizona, USA
Promoter DNA G-quadruplexes and their interactions with small molecules
10.00 – 10.15 Vitaly V Kuryavyi, Sloan-Kettering Institute for Cancer Research, USA
Parallel-stranded quadruplex structures of recombination hotspots from human and prokaryotic genomes
10.15 – 10.30 Brahim Heddi, Nanyang Technological University, Singapore
Insights into molecular recognition of G-quadruplexes
10.30 – 11.00 Coffee Break
 Session Chair: Jean-Louis Mergny
11.00 – 11.30 Jean-François Riou, Muséum National d’Histoire Naturelle, France
Replication: RPA to unfold G4 and G4 to direct origins
11.30 – 12.00 Hans J. Lipps, University Witten/Herdecke, Germany
The use of ciliated protozoa to study the regulation of G-quadruplex structures in vivo
12.00 – 12.30 Daniela Rhodes, Nanyang Technological University, Singapore
Structure of active dimeric human telomerase
12.30 – 14.00 Lunch
 Session Chair: Anh Tuân Phan
14.00 – 14.30 Ta-Chau Chang, Academia Sinica, Taiwan
Structural conversion of G-quadruplex, in solution and in cell
14.30 – 14.45 Daisuke Miyoshi, Konan University, Japan
Molecular crowding effects on functions of G-quadruplex ligands
14.45 – 15.30 Keynote Lecture 4
Stephen Neidle, University College London, UK
Quadruplex nucleic acids as targets for anticancer drug design
15.30 – 15.45 Closing


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